Infectious diseases continue to take a toll on human health, affecting all aspects of our lives. ?Fast development of preventative vaccines and therapeutic treatments has become imperative as the increased globalization of our modern world enables the rapid spread of infectious diseases.
Persistent use of antibiotics has provoked the emergence of multidrug resistant bacteria, creating therapeutic challenges that need to be adressed by the development of novel therapeutics or combination therapies.??
We offer a diverse product portfolio that helps scientists make critical discoveries through genomic analysis, in vitro, cell-based, and in vivo studies, accelerating their ability to develop treatments and vaccines.
Genetic information from viruses, bacteria and other infectious organisms plays a crucial role in diagnosing infection, investigating outbreaks, describing transmission patterns, monitoring antimicrobial resistance and last but not least, developing interventions such as vaccines. Next-generation-sequencing has made it possible, to investigate pathogens as well as mirobiome genomes at much greater detail and throughput.
Understanding host-pathogen interactions on a molecular, cellular or organism level is the basis for developing effective new treatments. To achieve physiological relevant results, today’s infectious disease research moves towards more complex disease models such as co-cultures or organoids that better resemble in vivo biology. Whether you want to analyze infection of cellular models or in vivo models, or study protein:protein interactions and identify PPI inhibitors, we provide the reagents, instruments and software you need to enable these applications.
When a pathogen infects the human body, a battle ensues between the host’s innate & adaptive immune systems and the pathogen’s virulence mechanisms and factors. Pathways such as MAP kinase, JAK/STAT, and NFκB play a central role in the antiviral immune response along with ligands such as IL-6, TNFα, and the INFs (-γ, -α, -β, and -λ). PerkinElmer offers a wide range of reagents, detection and imaging instruments enabling to study the antiviral immune response both in vitro and in vivo.
Antimicrobial research and drug discovery requires sensitive and reliable technologies to detect microbial growth and measure antimicrobial effects. We provide solutions to measure bacterial growth or viral titers, perform target-based, high-throughput drug screens or phenotypic screening and characterize bacterial phenotypes for antimicrobial resistance research using high-content analysis.
Continued discovery of new antiviral medications and vaccines is important for global human health, particularly as new viruses such as the novel Coronavirus or novel Influenza viruses can emerge quickly. We offer solutions for measuring virus neutralization, antiviral compound effects, antiviral immune response or for studying cytokine storm, which is associated with COVID-19.